My neighbor and i were arguing about this. I like 220 grain core-lokt in 30.06. He likes nosler 168 grain ballistic bullets his own loads in 30.06. We did not decide what works best for killing and saving meat. My son shot a small deer last year in muzzleloader season. With 280 grain lead sabot 100 grains of pyrodex. Heart shot exit below the the chest near the gut. No meat loss. So i think it's all in shot placement and bullet style and hardness.