So 60 is the new 57.5.
Biological age of humans reversed by years in groundbreaking study, scientists sugges
Andrew Griffin
9/6/2019
Scientists might be able to reverse process of ageing, a new study suggests.
Volunteers who were given a cocktail of drugs for a year actually “aged backwards”, losing an average of 2.5 years from their biological ages, according to the new study. The research showed that the marks on their genomes that represent their “epigenetic clock”, as well as their immune systems, actually improved despite the passing of time.
The scientists involved in the study were shocked by the results.
“I’d expected to see slowing down of the clock, but not a reversal,” researcher Steve Horvath from the University of California, Los Angeles told Nature, which first reported the findings. “That felt kind of futuristic.”
Scientists caution that the study was done with a very limited number of participants: only nine people took the drug cocktail, and there was no control group. But if it is confirmed by further research it could have huge impacts on healthcare, the treatment of disease and how people think about ageing.
In the study, participants were given a growth hormone and two diabetes medications. Scientists then monitored the test subjects’ epigenetic clocks, to understand the effect on how they aged.
The epigenetic clock is measured by the body’s epigenome – a record of chemical changes to an organism’s DNA. As people age, chemical modifications or tags are added to people’s DNA, and those change throughout their lives, so by looking at those tags a person’s biological age can be measured.
Researchers had actually intended to look at how the growth hormone would change the tissue in the thymus gland, which helps with the body’s immune functions and sits in the chest. It normally shrinks after puberty but they hoped to see whether it could be pushed to regrow, by giving participants the growth hormone.
It was only as a secondary consideration that researchers then checked how the drugs changed their epigenetic clocks. The study had finished when the analysis began.
Professor Horvath then looked at four different measures of the epigenetic clock to understand the differing ages of each of the patients. And he found that every one of them had reversed significantly – so significantly that he is optimistic about the results, despite the limited number of participants.
Scientists now hope to test the same effects with more people, through a controlled study, and with different age groups, ethnicities and with women.
The changes could still be seen in the blood of six participants who provided samples long after the study finished.
Some of the drugs used in the cocktail are already being researched as ways of fighting age-related diseases. But the discovery of the combined effect of the three of them could have major implications for the ways that a variety of different drugs are tested, scientists say.
https://www.independent.co.uk/news/...ing-turn-back-reverse-study-new-a9094261.html
9/6/2019
Scientists might be able to reverse process of ageing, a new study suggests.
Volunteers who were given a cocktail of drugs for a year actually “aged backwards”, losing an average of 2.5 years from their biological ages, according to the new study. The research showed that the marks on their genomes that represent their “epigenetic clock”, as well as their immune systems, actually improved despite the passing of time.
The scientists involved in the study were shocked by the results.
“I’d expected to see slowing down of the clock, but not a reversal,” researcher Steve Horvath from the University of California, Los Angeles told Nature, which first reported the findings. “That felt kind of futuristic.”
Scientists caution that the study was done with a very limited number of participants: only nine people took the drug cocktail, and there was no control group. But if it is confirmed by further research it could have huge impacts on healthcare, the treatment of disease and how people think about ageing.
In the study, participants were given a growth hormone and two diabetes medications. Scientists then monitored the test subjects’ epigenetic clocks, to understand the effect on how they aged.
The epigenetic clock is measured by the body’s epigenome – a record of chemical changes to an organism’s DNA. As people age, chemical modifications or tags are added to people’s DNA, and those change throughout their lives, so by looking at those tags a person’s biological age can be measured.
Researchers had actually intended to look at how the growth hormone would change the tissue in the thymus gland, which helps with the body’s immune functions and sits in the chest. It normally shrinks after puberty but they hoped to see whether it could be pushed to regrow, by giving participants the growth hormone.
It was only as a secondary consideration that researchers then checked how the drugs changed their epigenetic clocks. The study had finished when the analysis began.
Professor Horvath then looked at four different measures of the epigenetic clock to understand the differing ages of each of the patients. And he found that every one of them had reversed significantly – so significantly that he is optimistic about the results, despite the limited number of participants.
Scientists now hope to test the same effects with more people, through a controlled study, and with different age groups, ethnicities and with women.
The changes could still be seen in the blood of six participants who provided samples long after the study finished.
Some of the drugs used in the cocktail are already being researched as ways of fighting age-related diseases. But the discovery of the combined effect of the three of them could have major implications for the ways that a variety of different drugs are tested, scientists say.
https://www.independent.co.uk/news/...ing-turn-back-reverse-study-new-a9094261.html
1 - 10 of 10 Posts
No thanks, I like my gray hair.
In a book named: Younger Next Year. .... There is proof that you can become younger by taking better care of yourself.
I would be interested in any other changes in the people in that study.
2 toxins and a growth hormone to become younger? Add a grain of salt.
I would be interested in any other changes in the people in that study.
2 toxins and a growth hormone to become younger? Add a grain of salt.
I'm not interested. If they can get to the point where they can wind back the clock, to where I'm 21 years old again, call me.
Scientists caution that the study was done with a very limited number of participants: only nine people took the drug cocktail, and there was no control group.
---
Researchers had actually intended to look at how the growth hormone would change the tissue in the thymus gland, which helps with the body’s immune functions and sits in the chest. It normally shrinks after puberty but they hoped to see whether it could be pushed to regrow, by giving participants the growth hormone.
It was only as a secondary consideration that researchers then checked how the drugs changed their epigenetic clocks. The study had finished when the analysis began.
---
Some of the drugs used in the cocktail are already being researched as ways of fighting age-related diseases. But the discovery of the combined effect of the three of them could have major implications for the ways that a variety of different drugs are tested, scientists say.
---
Researchers had actually intended to look at how the growth hormone would change the tissue in the thymus gland, which helps with the body’s immune functions and sits in the chest. It normally shrinks after puberty but they hoped to see whether it could be pushed to regrow, by giving participants the growth hormone.
It was only as a secondary consideration that researchers then checked how the drugs changed their epigenetic clocks. The study had finished when the analysis began.
---
Some of the drugs used in the cocktail are already being researched as ways of fighting age-related diseases. But the discovery of the combined effect of the three of them could have major implications for the ways that a variety of different drugs are tested, scientists say.
Just the facts.
Just what this world needs, people living even longer and adding in record birth rates......................can you say overpopulation? We already can't feed or care for everyone now.
They should have looked at telomere length to see the effect of their "cocktail" on "lifespan. https://www.cuimc.columbia.edu/news/telomere-length-may-predict-remaining-lifespan
1 - 10 of 10 Posts
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