Most rifle powders burns too slowly for pistol calibers and thankfully small pistol primers aren't hot enough to set of the charge. Like Popeye and others have said, you're doing everything wrong. Stop, go back to square one and follow what's in the book before you end up maimed or dead.
In reloading the only "trial and error" should be within the recipe guidelines to fine tune a load for accuracy. Don't become a victim of your own ignorance.